Lyon 2020 HFA-ICOS baseline CV risk before combination RAF and MEK inhibitors. Very high if heart failure or cardiomyopathy; High if MI/CABG, stable angina, severe valvular disease, prior anthracycline, or ≥5 medium points; Medium if 2-4 medium points; Low if 0-1. Age ≥65 is Medium 1 only. LVEF 50-54 is Medium 2; this table has no printed LVEF <50 High row. Expert-opinion cardiotoxicity guide <2% / 2-9% / 10-19% / ≥20%. Not a treatment order.

Payment Options