IMWG 2014 myeloma requiring therapy (Rajkumar 2014). Met when clonal BMPC ≥10% or biopsy-proven plasmacytoma plus ≥1 MDE: hypercalcemia, renal insufficiency, anemia, osteolytic lesion (CRAB), or BMPC ≥60%, involved:uninvolved FLC ratio ≥100 with involved FLC ≥100 mg/L, or >1 focal MRI lesion ≥5 mm (SLiM). Not a diagnosis. Not smouldering MM, MGUS, POEMS, or amyloid. Not Greipp ISS or R-ISS. magent does not assay calcium, creatinine, hemoglobin, or FLC, and does not read MRI.

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