ASCO 2018 (Brahmer) irAE nephritis grade from creatinine vs baseline (mg/dL). First-match: 4 if dialysis or life-threatening; 3 if fold >3, creatinine >=4.0, or hospitalization; 2 if fold >2; 1 if fold >=1.5 or delta >=0.3; else 0. ICI action continue (0), consider_hold (1), hold (2), permanently_discontinue (3-4). Not a medical device, not a diagnosis, not KDIGO/AKIN, not a steroid dose; magent does not assay creatinine.

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