Jawhar 2019 mutation-adjusted risk score (MARS) for advanced systemic mastocytosis: age >60 (1), hemoglobin <10 g/dL (1), platelets <100×10^9/L (1), exactly one S/A/R mutation among SRSF2, ASXL1, RUNX1 (1) or two or more (2, not both). Max 5. Low 0–1 (training-set median OS not reached), intermediate 2 (3.9 y), high 3–5 (1.9 y). Not WHO SM criteria. magent does not sequence or assay labs.

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