Keefer 2016 Rome IV CAPS (formerly FAPS). rome_iv_caps is true iff continuous or nearly continuous abdominal pain, no or only occasional relationship with eating, defecation, or menses, pain limits daily functioning, pain is not feigned, not explained by another GI or medical condition, last-3-months criteria, and 6-month onset. Psychosocial comorbidity is copy-only. magent does not examine or judge feigning beyond the caller flag. Not a diagnosis, not IBS, not narcotic bowel syndrome.

Aziz 2016 Rome IV functional chest pain. rome_iv_chest_pain is true iff retrosternal chest pain or discomfort, no associated heartburn or dysphagia, not explained by GERD or eosinophilic esophagitis, no major esophageal motor disorder, last-3-months criteria, and 6-month onset. Caller assigns six flags, including cardiac rule-out. magent does not examine the patient, rule out ACS, or read manometry. Not a diagnosis, not functional heartburn, not reflux hypersensitivity, not globus.

Cotton 2016 Rome IV E1 biliary pain. rome_iv_biliary_pain is true iff epigastric or RUQ pain builds to a 30-min steady level, occurs at different intervals (not daily), interrupts activities or leads to an ED visit, and is not significantly related to bowel movements or relieved by posture or acid suppression. Supportive flags reported, not required. magent does not examine the patient or read ultrasound, HIDA, or ERCP. Not a diagnosis, not functional gallbladder, not biliary or pancreatic SOD.

Longstreth 2006 Rome III IBS. rome_iii_ibs is true iff pain or discomfort at least 3 days per month in the last 3 months, onset at least 6 months prior, and at least two of: improvement with defecation, change in stool frequency, and change in stool form. supporting_features_met is 0-3. Caller assigns five flags. magent does not examine the patient. Not a diagnosis, not Rome IV, not IBS subtype.

Hyams 2016 Rome IV H1a child/adolescent cyclic vomiting. rome_iv_child_cvs is true iff two_or_more_periods_intense_nausea_paroxysmal_vomiting_hours_to_days_within_6_months, episodes_stereotypical, episodes_separated_weeks_to_months_with_return_to_baseline, and not_attributed_to_another_condition. Caller assigns four flags. magent does not examine the child. Not a diagnosis, not neonate/toddler G3, not adult Rome IV CVS, not cannabinoid hyperemesis.

Cotton 2016 Rome IV E1b functional biliary SOD (former SOD type II). rome_iv_biliary_sod iff six E1 biliary-pain flags, enzymes XOR dilated bile duct, and no stones or other structural abnormalities. Type I (both findings) is organic stenosis, not this box. Type III (neither) is not this box. Supportive amylase/lipase, manometry, and scintigraphy are reported, not required. magent does not read labs, imaging, manometry, or ERCP. Not a diagnosis, not pancreatic SOD, not functional gallbladder.

Aziz 2016 Rome IV functional heartburn. rome_iv_heartburn is true iff burning retrosternal discomfort, no relief despite optimal antisecretory therapy, not explained by GERD or eosinophilic esophagitis, no major esophageal motor disorder, last-3-months criteria, and 6-month onset. Caller assigns six flags. magent does not prescribe PPI or read pH-impedance. Not a diagnosis, not globus, not reflux hypersensitivity, not Rome IV IBS.

Hyams 2016 Rome IV H2d child FAP-NOS. rome_iv_child_fap_nos is true iff episodic_or_continuous_abdominal_pain_not_solely_during_physiologic_events, pain_at_least_4_times_per_month, insufficient_criteria_for_ibs_fd_or_abdominal_migraine, not_explained_by_another_condition, and fulfilled_at_least_2_months. Caller assigns five flags including the IBS/FD/abdominal-migraine residual. magent does not re-run those tools. Not a diagnosis, not adult CAPS, not FAPS (dropped in Rome IV).

Hyams 2016 Rome IV H2a. True iff bothersome ≥4 days/month, symptoms_met ≥1 of 3 (postprandial fullness, early satiation, epigastric pain or burning not associated with defecation), exclusion, and 2-month duration. Item 4 is the exclusion, not a fourth symptom. PDS and EPS supportive features are copy-only. Caller assigns six flags. magent does not examine the child or parse EGD. Not a diagnosis. Not adult Rome IV FD.

Mearin 2016 Rome IV C3 functional diarrhea. rome_iv_diarrhea is true iff last-3-months criteria with 6-month onset, loose or watery stools without predominant abdominal pain or bothersome bloating in >25% of stools, and insufficient criteria for diarrhea-predominant IBS. Caller assigns three flags. magent does not examine the patient. Not a diagnosis. Adult C3 only. Not child G5, not IBS-D, not Rome IV IBS, not Manning, not functional constipation.

Hyams 2016 Rome IV H3b. rome_iv_child_fecal_incontinence is true iff developmental_age_older_than_4_years, duration_at_least_1_month, defecation_into_places_inappropriate_to_sociocultural_context, no_evidence_of_fecal_retention, and not_explained_by_another_condition. Item 2 is exclusion of fecal retention, not a symptom count. Duration is 1 month. Caller assigns five flags. magent does not examine the child. Not a diagnosis, not H3a functional constipation, not adult Rao 2016 F1.

Stanghellini 2016 Rome IV chronic nausea vomiting syndrome (CNVS, B3a). rome_iv_cnvs is true iff bothersome nausea at least 1 day per week and/or one or more vomiting episodes per week as one flag, self-induced vomiting eating disorders regurgitation and rumination excluded, no organic systemic or metabolic explanation including at upper endoscopy, last-3-months criteria, and 6-month onset. magent does not take a history or read endoscopy. Not a diagnosis, not CVS, not CHS, not rumination.

Aziz 2016 Rome IV esophageal globus. rome_iv_globus is true iff nonpainful lump or foreign-body sensation, occurrence between meals, no dysphagia or odynophagia, no gastric inlet patch, not explained by GERD or EoE, no major esophageal motor disorder, last-3-months criteria, and 6-month onset. Caller assigns eight flags. magent does not examine the patient or read endoscopy. Not a diagnosis, not functional heartburn, not Rome IV IBS, not CHS.

Stanghellini 2016 Rome IV adult CVS B3b. rome_iv_cvs is true iff stereotypical acute vomiting episodes lasting <1 week, ≥3 discrete episodes in the prior year and 2 in 6 months at least 1 week apart, absence of vomiting between episodes, last-3-months criteria, and 6-month onset. migraine_history is supportive and not required. Caller assigns eight flags. magent does not examine the patient. Not a diagnosis, not CHS, not pediatric CVS, not Rome IV IBS.

Reed 2010 ROSE (BRACES) for ED syncope: BNP ≥300 pg/mL, heart rate ≤50, fecal occult blood, hemoglobin ≤90 g/L, chest pain associated with syncope, Q wave not in lead III, and room-air SpO2 ≤94%. Each present criterion is 1 point (score 0-7). High-risk if any item is present. Caller assigns labs, vitals, FOB, chest pain, and the Q-wave flag. Not a medical device or disposition protocol; magent does not measure BNP, hemoglobin, or SpO2, and does not read an ECG.

Benninga 2016 Rome IV G5 Functional Diarrhea. rome_iv_infant_diarrhea is true iff daily_painless_recurrent_4_or_more_large_unformed_stools, symptoms_last_more_than_4_weeks, onset_between_6_and_60_months, and no_failure_to_thrive_if_caloric_intake_adequate. Rome IV is 4 or more stools (not Rome III's 3). Sleep-stool criterion was dropped and is not a flag. Caller assigns four flags. magent does not examine the child. Not a diagnosis, not adult Rome IV diarrhea, not a malabsorption workup.

Cotton 2016 Rome IV E2 pancreatic sphincter of Oddi disorder. rome_iv_pancreatic_sod is true iff documented recurrent episodes of pancreatitis, other etiologies of pancreatitis excluded, negative endoscopic ultrasound, and abnormal sphincter manometry. Caller assigns four flags. magent does not read EUS, manometry, labs, or imaging. Not a diagnosis, not biliary SOD, not functional gallbladder, not a sphincterotomy recommendation.

Stanghellini 2016 Rome IV rumination syndrome. rome_iv_rumination is true iff persistent or recurrent regurgitation of recently ingested food with subsequent spitting or remastication and swallowing, regurgitation not preceded by retching, last-3-months criteria, and 6-month onset. Supportive remarks (effortless, not preceded by nausea, recognizable food, ceases when acidic) are copy-only and not parsed. magent does not observe regurgitation. Not a diagnosis, not CHS, not CVS, not GERD.

Mearin 2016 Rome IV C6 OIC. rome_iv_oic is true iff new or worsening constipation when initiating, changing, or increasing opioid therapy, at least 2 of 6 symptoms (straining, lumpy/hard stools, incomplete evacuation, anorectal obstruction, manual maneuvers, fewer than 3 SBM/week), and loose stools rare without laxatives. symptom_count is 0-6. Caller assigns eight flags. magent does not examine the patient or prescribe opioids. Not a diagnosis, not functional constipation C2, not IBS, not child.

Keefer 2016 Rome IV NBS (D2). rome_iv_nbs is true iff chronic or frequently recurring abdominal pain on narcotics, pain not explained by a GI diagnosis, at least two of three NBS features, last-3-months criteria, and 6-month onset. nbs_features_met is 0-3. Caller assigns seven flags. ~75 mg oral morphine equivalent is copy-only. magent does not examine the patient or judge opioid dose. Not a diagnosis, not CAPS, not opioid-induced constipation.